in silico

adverb or adjective

in sil·​i·​co in-ˈsi-li-ˌkō How to pronounce in silico (audio)
: in or on a computer : done or produced by using computer software or simulation
in silico predictions
dissect a frog in silico

Did you know?

In silico literally means "in silicon" in New Latin, and is a nod to the importance of silicon in the creation of computer chips. (The same nod is given in the name "Silicon Valley.") In silico, which dates only to the early 1990s, is modeled on and often contrasted with two similarly-structured terms, both of which date to the pre-computer days right around the start of the 20th century. In vitro means "outside the living body and in an artificial environment." (In New Latin in vitro means "in glass.") In vivo translates as "in the living" in New Latin, and is used in English to mean "in the living body of a plant or animal."

Examples of in silico in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Because the area of science is machine learning, the experiments take place entirely in silico. The Physics Arxiv Blog, Discover Magazine, 13 Sep. 2024 And the consequences when controlling a real jet fighter can be a lot more severe than just testing in silico. Eric Berger, Ars Technica, 19 Apr. 2024 To be clear, Lake and his colleagues do not claim to have replicated in silico how toddlers actually learn. Sarah Zhang, The Atlantic, 5 Apr. 2024 Regulators must invest in a portfolio of programs that move beyond in silico testing to support use of AI in real, diverse clinical environments. Mark P. Sendak, STAT, 7 Feb. 2024 See all Example Sentences for in silico 

Word History

Etymology

New Latin, literally, in silicon

First Known Use

1987, in the meaning defined above

Time Traveler
The first known use of in silico was in 1987

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Dictionary Entries Near in silico

Cite this Entry

“In silico.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/in%20silico. Accessed 3 Dec. 2024.

Medical Definition

in silico

adjective or adverb
in sil·​i·​co in-ˈsi-li-ˌkō How to pronounce in silico (audio)
: in or on a computer : done or produced by using computer software or simulation
A structure as complex as the human brain … can't simply be replicated in silico; you can't draw up a blueprint for the myriad interconnections of our billions of neurons.Steven Johnson, The Nation
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